By DONALD G. MCNEIL JR.
Published: March 25, 2003
The New York Times
This article which appears in the New Yorker, introduces an interesting perspective about introducing vaccines and drugs to developing nations. Many developing nations simply lack the funds needed to buy drugs and vaccines for their people. The average amount of money spent on healthcare in some developing nations is only a few dollars where as in the US it is upwards of $5000 per capita. This huge discrepancy creates another similar problem. New drugs companies take massive risks when it comes to developing new drugs. Investments for such drugs can near a billion dollars and drug producers will target their drugs to the populations that will be most willing to pay high prices. Therefore, there has been a dearth in research and development for diseases afflicting developing nations. Companies realize that their investment, if directed towards solutions for developing nations, may not yield an acceptable return.
The author of this article introduces the concept of incentive and how the UK has promised to buy three hundred million doses of malaria vaccine once proven safe and effective. There are two ways that the governments of western nations entice companies to devote R&D to certain causes. The first method is called “push.” These push mechanisms are how much research has been directed. The government gives direct funding to labs and organizations that are committed to a certain cause. This is quite common and it is how the NIH does most of its funding now. The other approach to promoting research is through “pull” mechanisms. This is the strategy that the UK employed in its blanket claim. Pull mechanisms put the role of competition into the field of the drug companies. This approach seems highly efficient and more beneficial in the long run. It removes government funding of “failed attempts” as is common with push mechanisms.
It seems that world governments and private organizations such as the Bill and Melinda Gates Foundations current tend towards push mechanisms. And even though their contributions to the world of research and the movement to find cures are indispensible, their funding could be better spent by using them as “a carrot on the end of a stick.” By motivating companies to develop vaccines for malaria and other diseases that afflict the developing world, the governments and private organizations are in essence creating competition that will in the end aid the developing nations. This type of funding also removes the favoritism that arises with push mechanisms as politicians fund labs instead of labs directing research.
I think that it is heartening to see governments such as that of the UK taking a step in the right direction to bring funding to where it is most needed and in the manner that is most efficient.
This article, which appeared in the New York Times, chronicles the struggle that patients in Sierra Leone suffer from the lack of drugs. But the drugs that these patients don’t have access to are cheap and easy to produce. These drugs are morphine and other opiate derivatives. Patients in Sierra Leone and other African countries who are suffering through painful diseases do not have access many forms of palliative care. These patients usually don’t have access to the medical care that could have prevented their disease’s progression to such a stage. These early interventions tend to be expensive and most people cannot afford them, or even if they could, there is no medical facility nearby that could administer the treatment.
The lack of morphine leaves patients who are diagnosed with cancer, AIDS, and nerve damage with constant and intense pain. There is even a company in India that is producing oral morphine for only 1.7 cents a pill. So the simple question is: Why isn’t morphine being given to these patients? That is when politics meets healthcare.
It is a well known fact that opiates are highly addictive. However under proper medical supervision, these medications can be highly effective and not have intense adverse effects. This is why the government of Sierra Leone and some other African nations do not allow the importation or domestic growth of opiates. They believe that because there is a lack of widespread medical care and that because opiates could begin a huge addiction epidemic, no morphine should be administered.
Even though the outcome may seem a bit extreme, the logic of not bringing in opiates seems somewhat rational. Furthermore, the governments of these nations have relatively limited funds which tend to be directed to treatments for more immediate diseases such as diarrhea, pneumonia, tuberculosis and malaria. Yet there should be a better solution that letting millions suffer in pain. In the west, palliative care is almost a given birthright. People expect to not suffer disease in pain, and when they have to suffer it is only for short time. People in these nations never have had access to these medications, so the assumption that morphine will turn into an epidemic is just that, an assumption.
The words of the founder of a hospice in Sierra Leone resounded particularly strongly, “How can they say there is no demand when they don’t allow it?” he asked. “How can they be so sure that it will get out of control when they haven’t even tried it?”
By ETHAN GUILLEN
Published: October 3, 2007
The Boston Globe
As a student at an Ivy League University (Brown), I find this article especially interesting as it discusses the research university’s role in providing assistance to the developing world. Recently, led by its new president (Drew Faust), Harvard and other universities have joined together to state that they will provide whatever assistance they can to the developing world and will help ensure that any medicine that comes from university-sponsored research will go to aid individuals who need them. This is part of the larger effort of the Universities Allied for Essential Medicines (UAEM), a group dedicated to making university-produced cures available to the developing world.
I think it is admirable that the UAEM has criticized Abbot Industries for withdrawing helpful medications (essential for the survival of many Thai lives) in response to the Thai government allowing generic versions of drugs to be produced and sold to its citizens (generic drugs would have made treatment even more affordable for the Thai people). Additionally, the group is putting pressure on the
It is important for researchers to ensure that their research ends up benefitting those individuals who need it most. Many of these individuals are found in developing nations. One thing that UAEM has done was the “Philadelphia Consensus Statement,” which not only implores that the products of university research become available to the developing world, but also says that generic pharmaceutical companies should be able to provide generic versions of life-saving drugs, even if only the developing world. This would help reduce the enormous costs of providing healthcare in some of the poorest nations. This would then allow for an improved quality of life in those countries as they would have access to life-saving drugs in higher quantities.
I think it is amazing that these universities are committed to helping these developing nations, even if it does cost them some points with wealthy pharmaceutical companies. Because of its persistent efforts, the UAEM is gaining power, and if they can put some muscle behind their statements and remain committed to helping the developing world, they will manage to make a great difference in the developing world. The key to improving healthcare in these countries often comes in providing cutting-edge medicines at a low cost. Universities are often doing much of the research that eventually results in a functional drug. If they can stipulate that some of the drug must be made available to individuals in developing nations, it will do a lot of good. It is important for the UAEM to remember that pharmaceutical companies require university-led research, and, with that knowledge, may be able to exert sufficient leverage to help those in needy countries.
It is heartening to recognize that many universities are helping lead the way in developing low-cost drugs that can be given to other nations’ sick. This sort of commitment to fellow man and his (or her) health is admirable and has been seen repeatedly in my entries. Whether it is the
The AIDS Challenge
By MICHAEL GERSON
Published: October 8, 2007
The Boston Globe
This article outlines some of the problems associated with providing assistance to individuals with AIDS in
Although the
Currently, two million individuals are getting AIDS treatment in developing countries. Although this is an improvement over five to six years ago (where nearly no one was being treated), without proper prevention the number of individuals with AIDS (at a staggering 40 million) continues to increase by 4 million a year in these countries. This makes it seem highly unlikely that the
Despite the daunting numbers these nations face, the effort is laudable and it is making and impact, often in unexpected ways. I found it interesting that the number of people diagnosed with AIDS has increased as a result of more widespread treatment. This surprising information is a result of the greater desire to be tested when the prospect of treatment is on the horizon. Individuals who would have not even considered being tested in the past (because they had no hope of treatment and did not want to know) are now getting tested. In this way, increased treatment is required for a certain aspect of prevention. The more the people from developing countries know about AIDS, the longer they will be able to live, and the greater the chance for them to prevent transmission.
In terms of prevention, one of the biggest things that can be done is to provide pregnant AIDS-positive women with the drugs required to help prevent transmission of AIDS to newborns. This kind of technology is important in providing the next generation with the chance to be born AIDS free. I sincerely hope that those children, at least, can be given a fair chance at a full life.
Some nations are trying many other methods (as seen in the article), and this does help lower transmission rates. Overall, prevention of transmission would be required to lower the amount of individuals requiring treatment. The
The author of the article makes a great point towards the end of the article:
“Treatment and prevention, in the end, cannot be separated. And the goal of universal access to treatment seems morally unavoidable. However expensive this commitment might be, there is also a cost to letting 40 million people or more die - a cost the world should not be willing to pay.”
I completely agree. Prevention will make the goal of universal AIDS treatment more obtainable and, over time, the problem can be controlled and drastically reduced from the current state of epidemic. Granted, it is difficult to simultaneously fund effective treatment and prevention efforts, but perhaps some effective combination can be found to produce the best outcome. Additionally, both could be more effectively provided if other developed nations opted to fund AIDS operations in developing nations. Still, the key lies in some combination that helps stem the transmission of AIDS while simultaneously treating those unfortunate enough to have contracted the disease already. Hopefully, scientists will someday find a vaccine that is both effective in treating developing world populations while it can remain affordable. Until that time, those nations that are better off should help to fund the $32-51 million required to provide universal treatment needed by millions of AIDS sufferers. AIDS is one of the greatest obstacles in helping the developing world transition into the developed world where they can experience a greater quality of life for a longer period of time. It is also one of the obstacles that we, as a species, most need to overcome in the coming decades.
This article, highlights the involvement of everyone’s favorite Microsoft founder (and his wife) in improving vaccination coverage of children in some of the world’s poorest countries. Recognizing, in early 2000, that various
One of the problems associated with improving health outcomes in developing nations is the afflicted individuals’ or their government’s inability to afford the care they so desperately need. The disease can then spread and make the problem even more pronounced. This represents a good starting point in the improvement of public health in developing nations as those governments can help pass on some of the extensive costs to those in the developed world who can afford the treatments. Furthermore, as Bill Gates points out, it helps provide an infrastructure through which additional funding and vaccine distribution can occur.
Perhaps most interestingly, the GAVI alliance utilizes an incentive system to ensure the funding is going to the correct place and that those who need the care are truly benefiting from the millions contributed. They choose not to mandate how the money is spent, but only provide additional funding when the developing nations reach certain immunization coverage goals. The majority of nations (35 passed while only 5 failed) reach their respective immunization targets and receive additional funding (after verification by GAVI). This incentive scheme helps the two groups work together and helps overcome the “acceptance problem” whereby nations are sometime reluctant to utilize vaccines. Local governments are coordinated by the national governments and they work hard to reach their goals to secure additional funding. The acceptance of 70 “poor” nations will truly help improve childhood health worldwide.
Still, this foundation only provides money with which existing vaccines can be distributed, and is hardly enough for any one nation (who also lack the research facilities) to develop vaccines truly needed. Additionally, this alliance mainly deals with the three aforementioned conditions (tetanus, diphtheria, and pertussis). There are still many problems associated with HIV/AIDS, Polio, Malaria and Tuberculosis (to name a few) in the developing world, but these cures have either not be invented or are difficult to implement in developing countries. Raj’s entry (Nov. 12) highlights some additional problems found with providing vaccines to these nations.
This article shows how two individuals can begin changing the world by improving health outcomes for the truly poor. Their actions, along with their dedicated GAVI alliance, also inspired (or pushed) some developed nations into helping out. Through these kinds of initiatives, certain diseases may be eradicated and improve global health as was done with Smallpox in the previous century. The system is also overcoming some of the difficulties seen in previous attempts at improving vaccinations in developing nations and will hopefully innovate the way in which the international community deals with disease in developing nations. The extensive investments of a few private citizens will revolutionize healthcare in the areas that need it most while also setting up the infrastructure of a system by which developed nations can provide assistance to the neediest nations. Hopefully, a few more individuals/nations will be inspired by their actions so that humanity can turn the page on some of the most easily preventable diseases and focus on healthcare’s newest challenges.
Introducing New Vaccines Into Developing Countries: Obstacles, Opportunities, Complexities
By JOHN CLEMENS and LUIS JODARThe article goes on to explain the complexities that entail introducing new vaccines along with new opportunities to introduce vaccines that were previously non-existent (push mechanisms, private/nonprivate funding, and copy-cat vaccine production).
What was most interesting to me as I read this article was the 5th obstacle that the authors mentioned. It seems that the problem that faces most developing nations in receiving new vaccines is the cost. The focus of much health media today revolves around new discoveries in developed nations and how the new drug will cost hundreds of dollars per dose and how that is controversial because poorer nations cannot afford them. Yet, the authors of the article highlight the fact that this expensive medicine may not even work well in other populations. Furthermore, the authors mention how conducting secondary trials in developing nations after the drug has been released in developed nations can delay the release of crucial medications by years only to find out that the drug’s efficacy is compromised. The additional cost of such trials can also be insurmountable, creating a whole other set of complications.
So while a considerable amount of energy goes into the cost aspect of introducing new vaccines (that is not to say that cost is not important), a new focus should be introduced that ensures new vaccines are effective in different populations.